SRP8049
Periostin mouse
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
Synonym(s):
OSF-2, Osteoblast-specific factor 2, PC cell-derived growth factor
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
mouse
recombinant
expressed in CHO cells
tag
FLAG® tagged
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~85 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Postn(50706)
General description
Periostin (POSTN) is also called as osteoblast-specific factor 2. It is a matricellular protein, located in the alveolar walls. This gene is located on human chromosome 13q13.
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
Biochem/physiol Actions
Periostin (POSTN) participates in collagen fibrillogenesis. It plays a major role in the development of scar after traumatic spinal cord injury (SCI). Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis. It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.
Physical form
Lyophilized from PBS.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Periostin deficiency causes severe and lethal lung injury in mice with bleomycin administration.
Kondoh H, et al.
The Journal of Histochemistry and Cytochemistry, 64(7), 441-453 (2016)
Kai-Wen Yu et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 117(4), 292-300 (2018-01-08)
Appropriate mechanical stress plays an important role in regulating the proliferation and differentiation of osteoblasts, whereas high-level mechanical stress may be harmful and compromise cell survival. Periostin, a matricellular protein, is essential in maintaining functional integrity of bone and collagen-rich
Seong-Joon Koh et al.
PloS one, 11(2), e0149652-e0149652 (2016-02-20)
Periostin is a matricellular protein that interacts with various integrin molecules on the cell surface. Although periostin is expressed in inflamed colonic mucosa, its role in the regulation of intestinal inflammation remains unclear. We investigated the role of periostin in
Shoichiro Ohta et al.
PloS one, 12(3), e0174547-e0174547 (2017-03-30)
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was
Periostin promotes scar formation through the interaction between pericytes and infiltrating monocytes/macrophages after spinal cord injury.
Yokota K, et al.
The American Journal of Pathology, 187(3), 639-653 (2017)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service