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Y0001042

Omeprazole for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Omeprazole, 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O3S
CAS Number:
73590-58-6
Molecular Weight:
345.42
MDL number:
MFCD00083192
UNSPSC Code:
41116107
PubChem Substance ID:
329831235
NACRES:
NA.24
Pricing and availability is not currently available.

grade

pharmaceutical primary standard

API family

omeprazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Omeprazole for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Omeprazole Related Compound F and G mixture, United States Pharmacopeia (USP) Reference Standard

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Omeprazole Related Compound A, United States Pharmacopeia (USP) Reference Standard

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Omeprazole Related Compound I, United States Pharmacopeia (USP) Reference Standard

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Omeprazole Related Compound E, United States Pharmacopeia (USP) Reference Standard

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Omeprazole magnesium, United States Pharmacopeia (USP) Reference Standard

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Omeprazole Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1649

Omeprazole Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1650

Omeprazole Related Compound I, Pharmaceutical Secondary Standard; Certified Reference Material

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Omeprazole Related Compound B, United States Pharmacopeia (USP) Reference Standard

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Omeprazole, British Pharmacopoeia (BP) Reference Standard

PHR1988

Omeprazole Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

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Omeprazole Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

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Omeprazole Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1954

N′-Methyl Omeprazole, Pharmaceutical Secondary Standard; Certified Reference Material

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Esomeprazole sodium, European Pharmacopoeia (EP) Reference Standard

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2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H317,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

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Anju Nohria et al.
Journal of the American Heart Association, 3(1), e000609-e000609 (2014-01-07)
Inflammation is fundamental to the development of atherosclerosis. We examined the effect of anti-inflammatory doses of salicylate on endothelium-dependent vasodilation, a biomarker of cardiovascular risk, in a broad range of subjects. We performed a randomized, double-blind, placebo-controlled crossover trial evaluating
R P Myers et al.
The American journal of gastroenterology, 96(12), 3428-3431 (2002-01-05)
Omeprazole is a proton pump inhibitor that is used commonly in the treatment of acid-peptic disorders. Although omeprazole is generally well tolerated, serious adverse effects such as renal failure have been reported. Thus far, 17 cases of acute interstitial nephritis
Kazuhiro Shiizaki et al.
Molecular pharmacology, 85(2), 279-289 (2013-11-23)
Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While
A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole.
Lars Olbe et al.
Nature reviews. Drug discovery, 2(2), 132-139 (2003-02-04)
Vaibhav Mishra et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(6), 506-511 (2013-03-07)
In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation
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Questions

  1. Is the reference material "Omeprazole for peak identification (containing impurity E)"?

    1 answer

    1. Currently, the EP does not offer a standard for Omeprazole Impurity E, CAS 176219-04-8. There are two product options available, however neither are specified for peak identification. See the links below to review these products:

      USP Omeprazole Related Compound E
      https://www.sigmaaldrich.com/product/usp/1478527
      Pharmaceutical Secondary Standard; Certified Reference Standard, Omeprazole Related Compound E
      https://www.sigmaaldrich.com/product/sial/phr1649

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