B-035

Buprenorphine glucuronide solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): Buprenorphine-3-β-D-glucuronide solution
• Empirical Formula (Hill Notation): C₃₅H₄₉NO₁₀
• CAS Number: 101224-22-0
• Molecular Weight: 643.76
• EC Number: 200-659-6
• MDL number: MFCD08275541
• UNSPSC Code: 41116107
• PubChem Substance ID: 329773109
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland)
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c7O[C@@H]2[C@]3(CCN4CC8CC8)c57
• InChI: 1S/C35H49NO10/c1-31(2,3)32(4,42)20-15-33-10-11-35(20,43-5)30-34(33)12-13-36(16-17-6-7-17)21(33)14-18-8-9-19(26(46-30)22(18)34)44-29-25(39)23(37)24(38)27(45-29)28(40)41/h8-9,17,20-21,23-25,27,29-30,37-39,42H,6-7,10-16H2,1-5H3,(H,40,41)/t20-,21-,23+,24+,25-,27+,29-,30-,32+,33-,34+,35-/m1/s1
• InChI key: CZULHKGIAJASAA-WWIHBJMFSA-N

Description

General description

Buprenorphine glucuronide is a major urinary metabolite of the semi-synthetic opioid, buprenorphine. This Certified Spiking Solution^® is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pain prescription monitoring. Buprenorphine is used for the management of moderate chronic pain and for the treatment of opioid addiction.

Application

• Simplified processing and rapid quantification of buprenorphine, norbuprenorphine, and their conjugated metabolites in human plasma using UPLC-MS/MS: This study underscores the importance of buprenorphine glucuronide as a standard in pharmacokinetic research, facilitating accurate assessments of buprenorphine exposure during opioid use disorder treatment (Zhao et al., 2024).


• Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine: Highlights the application of buprenorphine glucuronide in developing methods for analyzing opioid metabolites in urine, crucial for monitoring drug therapy and compliance in clinical settings (Gqamana et al., 2024).


• Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome: The research uses buprenorphine glucuronide to study drug interactions in treating neonatal opioid withdrawal, demonstrating its significance in neonatal pharmacological research and therapy optimization (Tobacyk et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup