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764736

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane

PEG average Mn 2,000, PDLLA average Mn 2,000

Synonym(s):

PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

form

pellets

mol wt

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

degradation timeframe

2-5 weeks

transition temp

Tm 29-33 °C

PDI

<1.1 (typical PEG)
<1.2
<1.3 (overall)

storage temp.

2-8°C

General description

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†

Application

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

Features and Benefits

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

>230.0 °F

Flash Point(C)

> 110 °C

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Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to

Articles

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

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