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270873

Sigma-Aldrich

2-Hydroxyquinoline

98%

Synonym(s):

2-Quinolinol, Carbostyril

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About This Item

Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
Molecular Weight:
145.16
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

crystals

mp

198-199 °C (lit.)

solubility

alcohol: soluble(lit.)
diethyl ether: soluble(lit.)
dilute HCl: soluble(lit.)
water: slightly soluble (1 g/950mL)(lit.)

SMILES string

Oc1ccc2ccccc2n1

InChI

1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)

InChI key

LISFMEBWQUVKPJ-UHFFFAOYSA-N

General description

2-Hydroxyquinoline is a specific inhibitor of plaque paraoxonase1 (PON1).

Application

2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Edyta Stec et al.
Chembiochem : a European journal of chemical biology, 12(11), 1724-1730 (2011-06-15)
Aurachins are quinoline alkaloids isolated from the myxobacterium Stigmatella aurantiaca. They are substituted with an isoprenoid side chain and act as potent inhibitors in the electron transport chain. A biosynthetic gene cluster that contains at least five genes (auaA-auaE) has
Juan Peris-Vicente et al.
Antibiotics (Basel, Switzerland), 8(4) (2019-11-17)
A method based on micellar liquid chromatography was developed to determine oxolinic acid, ciprofloxacin, enrofloxacin, and sarafloxacin in eggs and egg products. The antimicrobial drugs were obtained in a micellar solution which was directly injected. The analytes were resolved using
Kamya Bhatnagar et al.
PloS one, 14(11), e0224650-e0224650 (2019-11-07)
The evolution of antibiotic resistance is influenced by a variety of factors, including the availability of resistance mutations, and the pleiotropic effects of such mutations. Here, we isolate and characterize chromosomal quinolone resistance mutations in E. coli, in order to
Elizabeth M Wagner et al.
Angiogenesis, 18(1), 1-11 (2014-08-26)
Expanded and aberrant bronchial vascularity, a prominent feature of the chronic asthmatic airway, might explain persistent airway wall edema and sustained leukocyte recruitment. Since it is well established that there are causal relationships between exposure to house dust mite (HDM)
Antonios Keirouz et al.
Journal of nanobiotechnology, 18(1), 51-51 (2020-03-20)
The state-of-the-art hernia meshes, used in hospitals for hernia repair, are predominantly polymeric textile-based constructs that present high mechanical strength, but lack antimicrobial properties. Consequently, preventing bacterial colonization of implanted prosthetic meshes is of major clinical relevance for patients undergoing

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