Skip to Content
Merck
All Photos(1)

Key Documents

SML3529

Sigma-Aldrich

GB83

≥98% (HPLC)

Synonym(s):

GB 83, GB-83, N-[(1S)-1-(Cyclohexylmethyl)-2-[[(1S,2S)-1-[(2,3-dihydrospiro[1H-indene-1,4′-piperidin]-1′-yl)carbonyl]-2-methylbutyl]amino]-2-oxoethyl]-5-isoxazolecarboxamide

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C32H44N4O4
CAS Number:
Molecular Weight:
548.72
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC[C@@H]([C@H](NC([C@@H](NC(C1=CC=NO1)=O)CC2CCCCC2)=O)C(N3CCC4(CC3)CCC5=C4C=CC=C5)=O)C

InChI

1S/C32H44N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-12,14,18,22-23,26,28H,3-6,9-10,13,15-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22?,26-,28-/m0/s1

InChI key

ZXMXAOYWSLZLQM-NZNGGYBSSA-N

Biochem/physiol Actions

GB83 is a serum stable, potent and selective antagonist of human protease activated receptor 2 (PAR2)(IC50 = 2 µM) that reversibly inhibit PAR2 activation by both proteases and PAR2 agonists. GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases by coagulation factor X (FXa) in atrial tissue slices

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice
Muley MM, Krustev E, Reid AR, McDougall JJ
Journal of Neuroinflammation, 14, 168-168 (2017)
Grant D Barry et al.
Journal of medicinal chemistry, 53(20), 7428-7440 (2010-09-30)
Human protease activated receptor 2 (PAR2) is a G protein-coupled receptor that is associated with inflammatory diseases and cancers. PAR2 is activated by serine proteases that cleave its N-terminus and by synthetic peptides corresponding to the new N-terminus. Peptide agonists
Alicja Bukowska et al.
European journal of pharmacology, 869, 172875-172875 (2019-12-27)
There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore, we aimed to investigate effects of exogenous FXa on mitochondrial and metabolic function as well as the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service