SML0278

SR 48692

≥98% (HPLC)

• Synonym(s): 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid, Meclinertant
• Empirical Formula (Hill Notation): C₃₂H₃₁ClN₄O₅
• CAS Number: 146362-70-1
• Molecular Weight: 587.07
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825286
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥2 mg/mL (warmed)
• storage temp.: −20°C
• SMILES string: COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O
• InChI: 1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)
• InChI key: DYLJVOXRWLXDIG-UHFFFAOYSA-N
• Gene Information: human ... NTSR1(4923)

Description

Application

SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:

• to explore the function of NTSR1 in glioblastoma (GBM) cells
• to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo
• to explore the involvement of NTSR1 versus NTSR2 in mice

Biochem/physiol Actions

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

Features and Benefits

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable