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P6777

Sigma-Aldrich

Phenelzine sulfate salt

Synonym(s):

Phenelzine hydrogen sulphate

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About This Item

Empirical Formula (Hill Notation):
C8H12N2 · H2O4S
CAS Number:
156-51-4
Molecular Weight:
234.27
EC Number:
205-856-0
MDL number:
MFCD00050687
UNSPSC Code:
12352200
PubChem Substance ID:
24278646
NACRES:
NA.77

biological source

synthetic

Assay

≥98% (iodine, titration)

form

powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

NNCCC1=CC=CC=C1.OS(=O)(O)=O

InChI

1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)

InChI key

RXBKMJIPNDOHFR-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128) , MAOB(4129)

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Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hwan-Suck Chung et al.
Neurochemical research, 37(10), 2117-2124 (2012-07-06)
Phenelzine is a potent monoamine oxidase inhibitor that is used in patients with depression. It is also well known that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, which suggests that NO is involved in the pathogenesis of depression.
Mee-Sook Song et al.
Journal of neurochemistry, 114(5), 1405-1413 (2010-06-19)
Reactive aldehydes have been implicated in the etiology of several neurological and psychiatric disorders, and there is considerable interest in drugs to counteract the actions of these aldehydes. Increased formaldehyde (FA) and up-regulation of semicarbazide-sensitive amine oxidase, which forms FA
The effect of riluzole augmentation in a patient with treatment-resistant obsessive-compulsive disorder, taking two other glutaminergic agents.
Nahla Mahgoub et al.
The Journal of neuropsychiatry and clinical neurosciences, 23(2), E24-E25 (2011-06-17)
Adeline Su-Yin Ngo et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 6(4), 431-434 (2010-07-24)
Phenelzine is an irreversible monoamine oxidase inhibitor (MAOI). Hypertensive reactions after ingestion of tyramine-rich foods such as cheese are well known. However, a review of the available medical literature found no previous reports of myocardial infarction resulting from the ingestion
Travis Musgrave et al.
Brain, behavior, and immunity, 25(8), 1677-1688 (2011-07-05)
Multiple sclerosis (MS) and the animal model, experimental autoimmune encephalomyelitis (EAE), are both accompanied by motor and non-motor symptoms. Pathological changes in the activities of key neurotransmitters likely underlie many of these symptoms. We have previously described disturbances in the
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