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Key Documents

I9660

Sigma-Aldrich

Anti-Integrin α2b (CD41) antibody, Mouse monoclonal

clone PM6/248, purified from hybridoma cell culture

Synonym(s):

Anti-CD41, Anti-CD41B, Anti-GP2B, Anti-GTA, Anti-ITGA2B integrin, alpha 2b

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PM6/248, monoclonal

form

buffered aqueous solution

species reactivity

baboon, human

concentration

~1.0 mg/mL

technique(s)

flow cytometry: 1-2 μg/mL using human platelets
immunoprecipitation (IP): suitable

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ITGA2B(3674)

General description

The gene ITGA2B (integrin subunit α 2b) encodes one of the 18 α subunits of integrins, which are transmembrane α/β heterodimers. The heterodimers, in mammals, are made up of a combination of one of 18 possible α subunits together with one of eight β subunits. The α and β subunits are type-I membrane proteins that contain a single transmembrane region linking a large extracellular domain and short noncatalytic cytoplasmic tail.

Immunogen

human platelet membranes

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The heterodimer αIIbβ3 functions primarily in platelet aggregation, a crucial process in hemostasis and thrombosis. Integrin αIIbβ3, also referred to as glycoprotein IIbIIIa is a major adhesion receptor on platelets that is capable of binding to fibrinogen upon platelet stimulation. Defects in this gene have been associated with Glanzmann thrombasthenia, an autosomal recessive bleeding disorder.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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