Safranin O is noted for its use in visualizing and quantifying the presence of glycosaminoglycans (GAGs) within a tissue sample. However, this application is not specifically tested, and no protocol is available to recommend. It is advised to refer to academic literature for guidance.
S2255
Safranin O
Dye content ≥85 %, Powder
Synonym(s):
Basic Red 2, Cotton Red, Gossypimine, Safranin T, Safranin Y or A
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C20H19ClN4
CAS Number:
Molecular Weight:
350.84
Colour Index Number:
50240
Beilstein:
3924099
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
Pricing and availability is not currently available.
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Product Name
Safranin O, Dye content ≥85 %
form
powder
Quality Level
composition
Dye content, ≥85%
technique(s)
microbe id | staining: suitable
pH
10 (20 °C, 10 g/L)
solubility
water: 1 mg/mL, clear, dark red to very dark red and red purple
εmax
1250-1650 at 530-534 nm in 50% ethanol
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Cl-].Cc1cc2nc3cc(C)c(N)cc3[n+](-c4ccccc4)c2cc1N
InChI
1S/C20H18N4.ClH/c1-12-8-17-19(10-15(12)21)24(14-6-4-3-5-7-14)20-11-16(22)13(2)9-18(20)23-17;/h3-11H,1-2H3,(H3,21,22);1H
InChI key
OARRHUQTFTUEOS-UHFFFAOYSA-N
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General description
Safranin O is a cationic dye, which displays less significant metachromasia. It is used to detect any variations in articular disease.[1] Safranin O binds specifically to polyanions.[2] It detects the amount of proteoglycan present in cartilages.[1] Safranin O is used as a marker for glycosaminoglycan depletion in osteoarthritis.[2] Safranin is used as a counter stain in Gram staining.[3]
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Good morning, how can i use the safranin O stain for detection of in vitro GAG ? I need the steps of preparation
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