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Key Documents

P38706

Sigma-Aldrich

Phthalazine

98%

Synonym(s):

β-Phenodiazine, 2,3-Benzodiazine, 2,3-Diazanaphthalene, Benzo[d]pyridazine

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About This Item

Empirical Formula (Hill Notation):
C8H6N2
CAS Number:
Molecular Weight:
130.15
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

crystals

bp

189 °C/29 mmHg (lit.)

mp

89-92 °C (lit.)

storage temp.

2-8°C

SMILES string

c1ccc2cnncc2c1

InChI

1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H

InChI key

LFSXCDWNBUNEEM-UHFFFAOYSA-N

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Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 3 - Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Design and synthesis of selective and potent orally active S1P5 agonists.
Henri Mattes et al.
ChemMedChem, 5(10), 1693-1696 (2010-09-04)
Fadi M Awadallah et al.
European journal of medicinal chemistry, 52, 14-21 (2012-03-24)
New phthalazine-based vasodilators were synthesized through the chloroacylation of the starting compound 1-hydrazinophthalazine 4 to give the two key intermediates 5 and 7. These intermediates were used to alkylate various cyclic amines to furnish the final compounds 6a-h and 8a-h.
Mohsen Shekouhy et al.
Ultrasonics sonochemistry, 19(2), 307-313 (2011-08-27)
A catalyst-free one-pot four component methodology for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction medium is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing
Hung-Kai Chen et al.
The Journal of biological chemistry, 287(8), 5253-5266 (2011-12-14)
Apolipoprotein E4 (apoE4), the major genetic risk factor for late onset Alzheimer disease, assumes a pathological conformation, intramolecular domain interaction. ApoE4 domain interaction mediates the detrimental effects of apoE4, including decreased mitochondrial cytochrome c oxidase subunit 1 levels, reduced mitochondrial
Kebin Li et al.
Analytical chemistry, 80(13), 4945-4950 (2008-05-30)
Arrays of Au nanowells (NWs) were fabricated by electron-beam lithography (EBL) and characterized by surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS). It is revealed that these Au NW arrays exhibit multiple SP resonances that can be tuned by

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