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1260001

USP

17α-Ethynylestradiol

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Ethinylestradiol

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About This Item

Formule empirique (notation de Hill):
C20H24O2
Numéro CAS:
57-63-6
Poids moléculaire :
296.40
Numéro Beilstein :
2419975
Numéro MDL:
MFCD00003690
Code UNSPSC :
41116107
ID de substance PubChem :
329749765
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

ethinyl estradiol

Fabricant/nom de marque

USP

Pf

182-183 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

Clé InChI

BFPYWIDHMRZLRN-SLHNCBLASA-N

Informations sur le gène

human ... ESR1(2099)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethinyl estradiol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Desogestrel and Ethinyl Estradiol Tablets
  • Drospirenone and Ethinyl Estradiol Tablets
  • Ethinyl Estradiol
  • Ethinyl Estradiol Tablets
  • Ethynodiol Diacetate and Ethinyl Estradiol Tablets
  • Levonorgestrel and Ethinyl Estradiol Tablets
  • Norethindrone Acetate and Ethinyl Estradiol Tablets

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Pictogrammes

Health hazardExclamation markEnvironment
GHS08,GHS07,GHS09

Mention d'avertissement

Danger

Mentions de danger

H302,H351,H360Fd,H410

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sigma-Aldrich

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Hongjian Zhang et al.
Clinical pharmacokinetics, 46(2), 133-157 (2007-01-27)
17alpha-Ethinylestradiol (EE) is widely used as the estrogenic component of oral contraceptives (OC). In vitro and in vivo metabolism studies indicate that EE is extensively metabolised, primarily via intestinal sulfation and hepatic oxidation, glucuronidation and sulfation. Cytochrome P450 (CYP)3A4-mediated EE
Per Hallgren et al.
Environmental toxicology and chemistry, 33(4), 930-936 (2014-03-13)
Endocrine-disrupting chemicals are known to alter the fitness of individual organisms via changes in growth, behavior, and reproduction. It is largely unknown, however, whether these effects cascade through the food web and indirectly affect other, less sensitive organisms. The authors
Andrew M Kaunitz et al.
Obstetrics and gynecology, 123(2 Pt 1), 295-303 (2014-01-10)
To compare a new low-dose levonorgestrel and ethinyl estradiol contraceptive patch (Patch) with a combination oral contraceptive (Pill; 100 micrograms levonorgestrel, 20 micrograms ethinyl estradiol) regarding efficacy, safety, compliance, and unscheduled uterine bleeding. Women (17-40 years; body mass index 16-60)
Robert W Flick et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 353-360 (2014-05-13)
Vitellogenin is frequently used as a biomarker of exposure to environmental estrogens due to its specificity and sensitivity. Appropriate incorporation of this biomarker into environmental monitoring and assessment necessitates evaluation of its critical performance parameters. In this study, we characterize
Lisa Baumann et al.
Toxicology and applied pharmacology, 278(3), 230-237 (2014-05-17)
The aim of the present study was to investigate the persistence of the feminizing effects of discontinued 17α-ethinylestradiol (EE2) exposure on zebrafish (Danio rerio). An exposure scenario covering the sensitive phase of sexual differentiation, as well as final gonad maturation
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