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SML0889

Sigma-Aldrich

bpV(phen)

≥95% V basis

Synonyme(s) :

Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate

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About This Item

Formule empirique (notation de Hill):
KVO5C12H8N2 · xH2O
Numéro CAS:
42494-73-5
Poids moléculaire :
350.24 (anhydrous basis)
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥95% V basis

Forme

powder

Conditions de stockage

protect from light

Couleur

faintly yellow to dark yellow

Solubilité

H2O: 20 mg/mL, clear

Température de stockage

−20°C

Chaîne SMILES 

O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]

InChI

1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;

Clé InChI

MQPXOTNOFVCXDA-UHFFFAOYSA-N

Actions biochimiques/physiologiques

bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.

Autres remarques

Light Sensitive

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Peroxovanadium?mediated protection against murine leishmaniasis: role of the modulation of nitric oxide.
Matte C, et al.
European Journal of Immunology, 30(9), 2555-2564 (2000)
Jinmin Miao et al.
Molecules (Basel, Switzerland), 28(19) (2023-10-14)
Src homology 2 domain-containing phosphatase 2 (SHP2) is an attractive target for cancer therapy due to its multifaceted roles in both tumor and immune cells. Herein, we designed and synthesized a novel series of proteolysis targeting chimeras (PROTACs) using a
Shuwei Liang et al.
Nature communications, 14(1), 4524-4524 (2023-07-28)
The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. Here we have explored the therapeutic
Hanhan Dai et al.
Aging, 12(12), 11717-11731 (2020-06-13)
Resveratrol is a common, naturally occurring polyphenol confirmed with inhibited the cellular effects of carcinogenesis. However, the molecular mechanism underlying resveratrol's action against hepatocellular carcinoma (HCC) is still unclear. In addition, MARCH1 promotes the initiation and progression of HCC, but

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