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Merck
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Principaux documents

SML0602

Sigma-Aldrich

Propiverine hydrochloride

≥98% (HPLC)

Synonyme(s) :

α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester, α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride, (1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride, 1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

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About This Item

Formule empirique (notation de Hill):
C23H29NO3 · HCl
Numéro CAS:
Poids moléculaire :
403.94
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

Essai

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

H2O: 5 mg/mL, clear (warmed)

Température de stockage

2-8°C

Chaîne SMILES 

[Cl-].[N+H]1(CCC(CC1)OC(=O)C(OCCC)(c3ccccc3)c2ccccc2)C

InChI

1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H

Clé InChI

KFUJMHHNLGCTIJ-UHFFFAOYSA-N

Description générale

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Actions biochimiques/physiologiques

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

CorrosionExclamation mark

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Heinrich Schulte-Baukloh et al.
Journal of pediatric urology, 8(4), 386-392 (2011-09-13)
To evaluate prospectively the efficacy and tolerability of propiverine for long-term treatment of neurogenic detrusor overactivity (NDO) in children. 17 children and adolescents with NDO (10 female, 7 male; average age at last consultation 13.0 years) were evaluated during long-term
A placebo-controlled, multicentre study comparing the tolerability and eYcacy of propiverine and oxybutinin in patients with urgency and urge incontinence.
Madersbacher H, et al.
BJU International, 84, 646-651 (1999)
Kimio Sugaya et al.
International journal of urology : official journal of the Japanese Urological Association, 19(5), 480-483 (2012-01-10)
It is not uncommon for patients with spinal cord injury to have both detrusor overactivity during the storage phase and detrusor underactivity during the voiding phase. However, there has been no information about the efficacy of combined treatment with cholinesterase
Saori Nishijima et al.
Life sciences, 89(13-14), 456-459 (2011-08-09)
We examined the influence of propiverine hydrochloride, an anticholinergic agent, on the micturition reflex, blood pressure, and plasma catecholamine levels in young rats and old rats. Male F344/DuCrlCrlj Fischer rats (young rats aged 2 months and old rats aged 26
F Donath et al.
International journal of clinical pharmacology and therapeutics, 49(6), 353-365 (2011-05-27)
Two comprehensively designed mono-centric ECG studies were performed to investigate the influence of propiverine hydrochloride and its main metabolite propiverine-N-oxide on cardiac function with regard to QTc prolongation, QTc dispersion and T-wave shape. The first study was conducted on 24

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