SML0488

Dobesilate Calcium

≥98% (HPLC)

• Synonyme(s) : 2,5-Dihydroxybenzenesulfonic acid calcium salt, 205E, Calcium 2,5-dihydroxybenzenesulfonate, Calcium Dobesilate, Hydroquinone calcium sulfonate
• Formule empirique (notation de Hill): C₆H₅O₅S · 0.5Ca
• Numéro CAS: 20123-80-2
• Poids moléculaire : 209.20
• Numéro MDL: MFCD00867249
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825438
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 15 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: [Ca++].Oc1ccc(O)c(c1)S([O-])(=O)=O.Oc2ccc(O)c(c2)S([O-])(=O)=O
• InChI: 1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2
• Clé InChI: QGNBTYAQAPLTMX-UHFFFAOYSA-L

Description

Description générale

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Application

Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.

Actions biochimiques/physiologiques

Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.

Dobesilate calcium inhibits the action of fibroblast growth factor by binding to its heparin-binding domain. It is also useful in treating rosacea and psoriasis, characterized with uncontrolled angiogenesis and vascular endothelial growth factor overexpression.

Caractéristiques et avantages

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable