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Key Documents

SAB5500057

Sigma-Aldrich

Anti-CD3 antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP162, affinity isolated antibody

Synonyme(s) :

Anti-CD3epsilon, Anti-IMD18, Anti-T3E, Anti-TCRE

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Produit recombinant

expressed in proprietary host

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

SP162, monoclonal

Espèces réactives

human (tested)

Réactivité de l'espèce (prédite par homologie)

rat, chicken, rabbit, mouse, pig, bovine, dog

Technique(s)

flow cytometry: 1:150
immunoblotting: 1:150
immunohistochemistry: 1:150

Isotype

IgG

Numéro d'accès UniProt

P07766

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CD3E(916)

Catégories apparentées

Description générale

CD3E (CD3e molecule) gene is mapped to human chromosome 11q23.3. This gene encodes fora subunit of T-cell regulator (TCR) protein complex. It possesses IgG (immunoglobulin G)-like extracelluar domain at the N-terminal, a transmembrane domain, a peptide bridge and an immunoreceptor tyrosine-based activation motif (ITAM) towards the cytoplasm. The protein also contains basic residue-rich sequence (BRS).
This antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. It stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.

Immunogène

Synthetic peptide corresponding to internal region of the epsilon chain of human CD3 protein.

Application

Anti-CD3 antibody, Rabbit monoclonal has been used in immunohistochemistry.

Actions biochimiques/physiologiques

CD3E (CD3e molecule) gene is associated with actin cytoskeletal rearrangement, through activation of a number of signaling pathways. CD3E is essential for membrane binding of T-cell regulator (TCR) protein complex.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

SnapShot: forkhead transcription factors II
Tuteja G and Kaestner KH
Cell, 131(1), 192-192 (2007)
Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells
Paensuwan P, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 33(3) (2015)
Ionic CD3- Lck interaction regulates the initiation of T-cell receptor signaling
Li L, et al.
Proceedings of the National Academy of Sciences of the USA, 114(29), E5891-E5899 (2017)
The progression of CD56+ myeloid sarcoma: A case report and literature review
Wang X, et al.
Oncology Letters, 11(5), 3091-3096 (2016)
Xuan He et al.
Cell, 184(13), 3467-3473 (2021-06-17)
We previously reported that a single immunization with an adenovirus serotype 26 (Ad26)-vector-based vaccine expressing an optimized SARS-CoV-2 spike (Ad26.COV2.S) protected rhesus macaques against SARS-CoV-2 challenge. To evaluate reduced doses of Ad26.COV2.S, 30 rhesus macaques were immunized once with 1 ×
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