SAB4700215
Monoclonal Anti-CD63 antibody produced in mouse
clone MEM-259, purified immunoglobulin, buffered aqueous solution
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
MEM-259, monoclonal
Forme
buffered aqueous solution
Espèces réactives
human
Concentration
1 mg/mL
Technique(s)
flow cytometry: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CD63(967)
Description générale
Cluster of differentiation 63 (CD63), also known as melanoma 1 antigen, is encoded by the gene mapped to human chromosome 12q13.2. The encoded protein belongs to the transmembrane 4 superfamily (TM4SF). CD63 is an integral membrane glycoprotein expressed in late endosomes and lysosomes and is also present in the platelet dense granule membrane.
The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Immunogène
HPB-ALL T cell line
Application
Monoclonal Anti-CD63 antibody produced in mouse has been used in flow cytometry and confocal imaging.
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Actions biochimiques/physiologiques
Cluster of differentiation 63 (CD63) is one of the platelet activation marker, which plays a vital role in platelet aggregation, adhesion to collagen, uptake of oxidized low-density lipoprotein (LDL) in vitro and regulation of angiogenesis. Inadequate expression of CD63 results in the autosomal recessive inherited disorder, Hermansky-Pudlak syndrome. CD63 is associated with various cellular functions, such as cellular adhesion, cell differentiation, migration, carcinogenesis and tumor progression. CD63 is highly expressed in the initial stage of Merkel cell carcinoma and decreased in later stages; therefore, CD63 is considered to be a potential prognostic factor for this malignancy.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.
Nishibori M
The Journal of Clinical Investigation, 91, 1775-1782 (1993)
Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression.
Woegerbauer M
Modern Pathology, 23, 751-762 (2010)
A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase.
Berditchevski F
The Journal of Biological Chemistry, 272, 2595-2598 (1997)
Satoshi Murakami et al.
Scientific reports, 9(1), 671-671 (2019-01-27)
IgG is an indispensable biological experimental tool as well as a widely-used therapeutic protein. However, cell culture-based expression of monoclonal IgG is costly and time-consuming, making this process difficult to use for high-throughput screening in early-stage evaluation of biologics. With
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas
Kannengiesser C
Molecular Oncology, 1, 425-430 (2008)
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