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Key Documents

SAB4504563

Sigma-Aldrich

Anti-phospho-Tau (pThr231) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU, Anti-tau-40

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 78 kDa

Espèces réactives

mouse, human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

Numéro d'accès NCBI

P10636

Numéro d'accès UniProt

P10636

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pThr231)

Informations sur le gène

human ... MAPT(4137)

Description générale

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. This gene is expressed in neurons but is most prominent in axons.

Immunogène

The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Thr231.

Immunogen Range: 521-570

Actions biochimiques/physiologiques

MAPT (microtubule associated protein tau) participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure. Removal of MAPT results in developmental delay and learning disability.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Pariya Khodabakhsh et al.
CNS neuroscience & therapeutics, 29(1), 91-103 (2022-10-04)
The peptidyl-prolyl cis/trans isomerase, Pin1, has a protective role in age-related neurodegeneration by targeting different phosphorylation sites of tau and the key proteins required to produce Amyloid-β, which are the well-known molecular signatures of Alzheimer's disease (AD) neuropathology. The direct
Patricia G Saletti et al.
Epilepsia open, 8(2), 586-608 (2023-04-08)
We used the lateral fluid percussion injury (LFPI) model of moderate-to-severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post-traumatic seizures or neuromotor functional recovery (neuroscores), considering the effect of levetiracetam, which is commonly given after
Microdeletion encompassing MAPT at chromosome 17q21. 3 is associated with developmental delay and learning disability.
Shaw-Smith C, et al.
Nature Genetics, 38(9), 1032?1037-1032?1037 (2006)
Brendan P Major et al.
Frontiers in neurology, 11, 549624-549624 (2020-10-30)
Studies have indicated that concussive and sub-concussive brain injuries that are frequent during collision sports may lead to long-term neurological abnormalities, however there is a knowledge gap on how biological sex modifies outcomes. Blood-based biomarkers can help to identify the
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
Skipper L, et al.
American Journal of Human Genetics, 75(4), 669-677 (2004)
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