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Principaux documents

SAB4500487

Sigma-Aldrich

Anti-PARP (Cleaved-Asp214) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

ADP-ribosyltransferase 1, ADPRT, ADPRT1, PARP, pADPRT-1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 24 kDa

Espèces réactives

mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

Numéro d'accès NCBI

P09874

Numéro d'accès UniProt

P09874

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

proteolytically cleaved (Asp214)

Informations sur le gène

human ... PARP1(142)

Description générale

Anti-PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP (Cleaved-Asp214) protein.
PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear protein that consists of three functional domains. It belongs to the PARP family. It is located on chromosome 1q42.

Immunogène

The antiserum was produced against synthesized peptide derived from human PARP.

Immunogen Range: 165-214

Application

Anti-PARP (Cleaved-Asp214) antibody has been used in Western Blotting.

Actions biochimiques/physiologiques

PARP1 (poly (ADP-ribose) polymerase 1) participates in DNA repair. It serves as a facilitator of homologous recombination. It controls transcription by regulating chromatin structure, altering DNA methylation patterns, acting as a co-regulator of transcription factors and interacting with chromatin insulators. It also plays an important role in the protection of cardiovascular system.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

PARP-1 protein expression in glioblastoma multiforme
Galia A, et al.
European Journal of Histochemistry, 56 (2012)
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Murai J, et al.
Cancer Research, 72 (2012)
Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells
Wang X, et al.
Toxicology Letters (2017)
Loss of ?(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cells
Wang X, et al.
Toxicological Sciences, 141 (2014)
Huajun Xi et al.
Molecular medicine reports, 24(3) (2021-07-20)
Forkhead‑box gene 1 (FOXG1) has been reported to serve an important role in various malignancies, but its effects on nasopharyngeal cancer (NPC) remain unknown. Thus, the present study aimed to investigate the specific regulatory relationship between FOXG1 and NPC progression. Tumor tissues and
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