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Principaux documents

SAB2702364

Sigma-Aldrich

Monoclonal Anti-Iba1 antibody produced in mouse

clone GT10312, affinity isolated antibody

Synonyme(s) :

AIF-1, IBA1, IRT-1, IRT1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

GT10312, monoclonal

Forme

buffered aqueous solution

Poids mol.

17kDa

Espèces réactives

mouse, human, rat

Concentration

2.03mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1000
indirect immunofluorescence: suitable
western blot: 500-3000

Isotype

IgG1

Numéro d'accès UniProt

P55008

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... AIF1(199)

Description générale

Ionized calcium-binding adapter molecule 1 (IBA1), also called the allograft inflammatory factor 1 (AIF1) is mapped to human chromosome 6p21.33. It encodes a 17 kDa protein and comprises calcium binding EF hand motif. IBA1 is expressed in lung, tonsil, lymph node and spleen. In addition,it is also expressed in macrophages and glial cells.

Immunogène

Recombinant protein encompassing a sequence within the center region of human Iba1.

Application

Monoclonal Anti-Iba1 antibody produced in mouse has been used:
  • in the double immunofluorescence
  • in the immunofluorescence
  • in immunohistochemistry

Actions biochimiques/physiologiques

Ionized calcium-binding adapter molecule 1 (IBA1) interacts with filamentous actin (F‐actin) and L‐fimbrin. Its expression is modulated during injury. Inflammatory cytokines also induce IBA1 expression. IBA1 expression is implicated in the graft rejection in coronary artery vasculopathy (CAV). It is highly expressed in hepatocellular carcinoma and may serve a potential marker and therapeutic target. Increased expression of AIF1 in synovial fluid and peripheral blood monocytes is implicated in rheumatoid arthritis.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Autres remarques

Purification: Affinity purified by Protein G

Forme physique

Phosphate-buffered saline, no preservative added.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Sarah Thomas Broome et al.
International journal of molecular sciences, 23(3) (2022-02-16)
A pharmacological and genetic blockade of the dopamine D3 receptor (D3R) has shown to be neuroprotective in models of Parkinson's disease (PD). The anxiolytic drug buspirone, a serotonin receptor 1A agonist, also functions as a potent D3R antagonist. To test
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease
Cramer PE, et al.
Neurobiology of Aging, 64, 92-106 (2018)
Repeated injections of human umbilical cord blood-derived mesenchymal stem cells significantly promotes functional recovery in rabbits with spinal cord injury of two noncontinuous segments
Yang C, et al.
Stem Cell Research & Therapy, 9(1), 136-136 (2018)
Chen Guang Yu et al.
International journal of molecular sciences, 23(1) (2022-01-12)
Microglia/astrocyte and B cell neuroimmune responses are major contributors to the neurological deficits after traumatic spinal cord injury (SCI). Bruton tyrosine kinase (BTK) activation mechanistically links these neuroimmune mechanisms. Our objective is to use Ibrutinib, an FDA-approved BTK inhibitor, to
Treadmill exercise decreases Abeta deposition and counteracts cognitive decline in APP/PS1 mice, possibly via hippocampal microglia modifications
Zhang X, et al.
Frontiers in Aging Neuroscience, 11, 78-78 (2019)
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