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S7947

Sigma-Aldrich

Stattic

≥98% (HPLC), powder

Synonyme(s) :

6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

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About This Item

Formule empirique (notation de Hill):
C8H5NO4S
Numéro CAS:
19983-44-9
Poids moléculaire :
211.19
Numéro MDL:
MFCD00173799
Code UNSPSC :
12352200
ID de substance PubChem :
329824592
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: >20 mg/mL

Chaîne SMILES 

[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

Clé InChI

ZRRGOUHITGRLBA-UHFFFAOYSA-N

Application

Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.
Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5

Actions biochimiques/physiologiques

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.2 Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,3 and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.4
Stattic is an irreversible STAT3 activation inhibitor.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway
Cheng M, et al.
American Journal of Translational Research, 11(4), 2317-2317 (2019)
Yunbao Pan et al.
PloS one, 8(1), e54565-e54565 (2013-02-06)
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia, Africa and Alaska. Radiotherapy and cisplatin-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are
Jochen Schust et al.
Chemistry & biology, 13(11), 1235-1242 (2006-11-23)
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that transmit signals from the cell membrane to the nucleus. One family member, STAT3, is constitutively activated by aberrant upstream tyrosine kinase activities in a
Karen Kwofie et al.
Respiratory research, 16, 14-14 (2015-04-08)
Regulation of human airway smooth muscle cells (HASMC) by cytokines contributes to chemotactic factor levels and thus to inflammatory cell accumulation in lung diseases. Cytokines such as the gp130 family member Oncostatin M (OSM) can act synergistically with Th2 cytokines
Nikolaos Sismanopoulos et al.
PloS one, 7(3), e33271-e33271 (2012-03-14)
Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml) induces gene expression and secretion of VEGF from human LAD2. IL-9
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