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S4776

Sigma-Aldrich

Somatotropin from human pituitary

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder

Synonyme(s) :

STH

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About This Item

Numéro MDL:
MFCD00081960
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Produit recombinant

expressed in E. coli

Niveau de qualité

200

Stérilité

non-sterile

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50

Poids mol.

predicted mol wt ~22 kDa

drug control

Home Office Schedule 4.2

Impuretés

endotoxin, tested

Solubilité

PBS: 0.100 mL, clear, colorless (with 0.1% BSA )

Numéro d'accès UniProt

P01241
P10912

Conditions d'expédition

ambient

Température de stockage

−20°C

Informations sur le gène

human ... GH1(2688) , GHR(2690)

Description générale

Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.

Application

Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.

Actions biochimiques/physiologiques

Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.

Forme physique

Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.

Reconstitution

It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Quantitative analysis of the expression of whey acidic protein (WAP) mRNA in the prolactin-responsive mouse mammary gland epithelial cell line, HC11
Kawamata, Yuji, et al
Journal of Reproduction and Development (2001)
Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
Takahiro Sawada
PLoS ONE (2017)
Yun Pang et al.
Kidney international, 90(6), 1357-1367 (2016-10-18)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by overproduction of numerous autoantibodies. Many studies have sought to identify such biomarkers to distinguish patients with active lupus nephritis from SLE patients without renal involvement. Because antibodies to complement C1q
Kin-Sing Wong et al.
Journal of chromatography. A, 1478, 35-42 (2016-12-05)
Growth hormone (GH), or somatotropin, is a protein that may enhance physical performance and facilitate growth and wound healing. For this reason, growth hormones and their recombinant analogues are prohibited in human sports by the World Anti-Doping Agency (WADA) and
Maximilian Bielohuby et al.
Disease models & mechanisms, 7(11), 1263-1273 (2014-09-23)
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact
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