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S4521

Sigma-Aldrich

Saponin from Quillaja sp.

Sapogenin content 20-35 %

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About This Item

Numéro CAS:
8047-15-2
Numéro CE :
232-462-6
Numéro MDL:
MFCD00081981
Code UNSPSC :
12161902
Nomenclature NACRES :
NA.32

Description

non-ionic

Niveau de qualité

300

Composition

Sapogenin content, 20-35%

Technique(s)

HPLC: suitable
protein quantification: suitable

Cendres sulfatées

≤10%

Description générale

Saponins are steroid or triterpenoid glycosides. They are biosurfactants that have several uses in the food and cosmetic industry.

Application

Saponin from Quillaja bark has been used:
  • to stain fertilized oocytes
  • in the analysis of intracellular cytokine production
  • to permeabilize dendritic cells

Actions biochimiques/physiologiques

Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.
Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Notes préparatoires

Purified to remove low molecular weight contaminants 

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319,H335

Classification des risques

Eye Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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A few membrane-intercalating amphipaths have been observed to stimulate the interaction of cholesterol with cholesterol oxidase, saponin and cyclodextrin, presumably by displacing cholesterol laterally from its phospholipid complexes. We now report that this effect, referred to as cholesterol activation, occurs
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