Accéder au contenu
Merck
Toutes les photos(2)

Principaux documents

Voir toute la documentation

S3442

Sigma-Aldrich

SB 216763

>98% (HPLC)

Synonyme(s) :

3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Formule empirique (notation de Hill):
C19H12N2O2Cl2
Numéro CAS:
280744-09-4
Poids moléculaire :
371.22
Numéro MDL:
MFCD09753369
Code UNSPSC :
12352200
ID de substance PubChem :
24278616
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

>98% (HPLC)

Couleur

orange

Solubilité

DMSO: soluble 20 mg/mL
H2O: insoluble

Auteur

GlaxoSmithKline

Température de stockage

−20°C

Chaîne SMILES 

Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14

InChI

1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)

Clé InChI

JCSGFHVFHSKIJH-UHFFFAOYSA-N

Informations sur le gène

human ... GSK3A(2931) , GSK3B(2932)

Application

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Actions biochimiques/physiologiques

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.
Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

Sold for research purposes under agreement from Glaxo­Smith­Kline

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 7

1 of 7

Kenpaullone ≥98%

Sigma-Aldrich

K3888

Kenpaullone

GSK-3β Inhibitor VIII The GSK-3β Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

361549

GSK-3β Inhibitor VIII

TWS119 ≥98% (HPLC)

Sigma-Aldrich

SML1271

TWS119

BNTX maleate salt hydrate ≥98% (HPLC)

Sigma-Aldrich

B8312

BNTX maleate salt hydrate

BIO-Acetoxime ≥98% (HPLC)

Sigma-Aldrich

SML0531

BIO-Acetoxime

Wnt Agonist The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

681665

Wnt Agonist

Cimaterol VETRANAL®, analytical standard

Supelco

32568

Cimaterol

Jonathan S Miller et al.
PloS one, 9(2), e88026-e88026 (2014-02-08)
The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of the two kinases.
Eric R Gross et al.
American journal of physiology. Heart and circulatory physiology, 294(3), H1497-H1500 (2008-01-29)
Previous studies in our laboratory suggest that an acute inhibition of glycogen synthase kinase 3 (GSK3) by SB-216763 (SB21) is cardioprotective when administered just before reperfusion. However, it is unknown whether the GSK inhibitor SB21 administered 24 h before ischemia
Shuzhen Guo et al.
Stroke, 40(2), 652-655 (2008-11-01)
We recently reported that delayed lithium therapy can improve stroke recovery in rats by augmenting neurovascular remodeling. We tested the hypothesis that lithium can promote the expression of growth factors in brain endothelial cells and astrocytes. Human brain microvascular endothelial
Giulia Rossana Gulino et al.
Environmental health perspectives, 124(6), 776-784 (2015-12-20)
Chrysotile asbestos accounts for > 90% of the asbestos used worldwide, and exposure is associated with asbestosis (asbestos-related fibrosis) and other malignancies; however, the molecular mechanisms involved are not fully understood. A common pathogenic mechanism for these malignancies is represented
Huan Deng et al.
The Journal of biological chemistry, 283(15), 10198-10207 (2008-02-07)
We examined the role of glycogen synthase kinase-3beta (GSK-3beta) inhibition in airway smooth muscle hypertrophy, a structural change found in patients with severe asthma. LiCl, SB216763, and specific small interfering RNA (siRNA) against GSK-3beta, each of which inhibit GSK-3beta activity
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique