R2500

all trans-Retinal

powder, ≥98%

• Synonyme(s) : Vitamin A aldehyde
• Formule empirique (notation de Hill): C₂₀H₂₈O
• Numéro CAS: 116-31-4
• Poids moléculaire : 284.44
• Numéro MDL: MFCD00001550
• Code UNSPSC : 12352205
• ID de substance PubChem : 24899355
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Pureté: ≥98%
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: yellow
• Pf: 62-64 °C
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H]C(=O)\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
• InChI: 1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
• Clé InChI: NCYCYZXNIZJOKI-OVSJKPMPSA-N

Description

Description générale

All trans-Retinal is one of the major derivatives of vitamin A group. A variety of food serves as a source of vitamin A. It is predominant in liver and among the brightly colored vegetables.

Application

All trans-Retinal has been used:

• in optogenetic experiments
• in electrophysiological experiment
• to study the effect of AKR1B10 (aldo-keto reductase (AKR) superfamily member) on the conversion of retinal to retinol in the airway epithelium
• in decidual transformation of human endometrial stromal cells

Actions biochimiques/physiologiques

All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells. Retinal isomers are also chromophores that bind to opsins, a family of G-protein-linked transmembrane proteins, to form photosensitive receptors in visual and nonvisual systems. All-trans retinal is a potent photosensitizer.

Conditionnement

Sealed ampule.