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P9386

Sigma-Aldrich

Poly-L-histidine

mol wt 5,000-25,000

Synonyme(s) :

L-Histidine homopolymer

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About This Item

Numéro CAS:
26062-48-6
Numéro MDL:
MFCD00166382
Code UNSPSC :
12352209
ID de substance PubChem :
24899031
Nomenclature NACRES :
NA.26

Forme

powder or solid

Niveau de qualité

200

Poids mol.

5,000-25,000

Couleur

white to light yellow

Application(s)

cell analysis

Température de stockage

−20°C

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

Clé InChI

HNDVDQJCIGZPNO-YFKPBYRVSA-N

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Description générale

Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.

Application

Poly-L-histidine has been used:
  • as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
  • as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
  • in screening its anti-prion activity in cell based and in vivo anti-prion assay

Actions biochimiques/physiologiques

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

Remarque sur l'analyse

Molecular weight by MALLS.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
Dalmasso PR, et al.
Sensors and Actuators B, Chemical, 173(5), 732-736 (2012)
Wooram Park et al.
Biomaterials, 33(34), 8848-8857 (2012-09-11)
For long-term, sustained protein delivery, a new, star-shaped block copolymer composed of methoxy poly(ethylene glycol) (mPEG), branched oligoethylenimine (bOEI), and poly(l-histidine) (pHis) was synthesized via the multi-initiation and ring-opening polymerization (ROP) of His N-carboxy anhydride (NCA) on bOEI with a
Rong Liu et al.
International journal of nanomedicine, 7, 4433-4446 (2012-08-28)
Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore their drug-release behavior. The drug-loaded
Poly (l-histidine)-PEG block copolymer micelles and pH-induced destabilization
Lee ES, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 90(3), 363-374 (2003)
Frank Morgner et al.
Sensors (Basel, Switzerland), 11(10), 9667-9684 (2011-12-14)
Förster resonance energy transfer (FRET) from luminescent terbium complexes (LTC) as donors to semiconductor quantum dots (QDs) as acceptors allows extraordinary large FRET efficiencies due to the long Förster distances afforded. Moreover, time-gated detection permits an efficient suppression of autofluorescent
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