P7265

Prostaglandin A₁

≥98% (HPLC), powder, NF-κB inhibitor

• Synonyme(s) : (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA₁
• Formule empirique (notation de Hill) : C₂₀H₃₂O₄
• Numéro CAS: 14152-28-4
• Poids moléculaire : 336.47
• NACRES: NA.77
• PubChem Substance ID: 24898834
• UNSPSC Code: 12352211
• MDL number: MFCD00077858
• Beilstein/REAXYS Number: 2003401
• Assay: ≥98%
• Form: powder

Propriétés

• Nom du produit: Prostaglandin A₁, synthetic
• biological source: synthetic
• Quality Segment: 200
• assay: ≥98%
• form: powder
• storage temp.: −20°C
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
• InChI: 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
• InChI key: BGKHCLZFGPIKKU-LDDQNKHRSA-N

Description

Biochem/physiol Actions

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360F
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)