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P3635

Sigma-Aldrich

5β-Pregnane-3α,20α-diol glucuronide

≥98.00% (TLC), powder, progesterone metabolite

Synonyme(s) :

P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide

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About This Item

Formule empirique (notation de Hill):
C27H44O8
Numéro CAS:
1852-49-9
Poids moléculaire :
496.63
Numéro MDL:
MFCD00056522
Code UNSPSC :
51111800
ID de substance PubChem :
24898430
Nomenclature NACRES :
NA.77

product name

5β-Pregnane-3α,20α-diol glucuronide,

Stérilité

non-sterile

Pureté

≥98.00% (TLC)

Forme

powder

Technique(s)

enzyme immunoassay: suitable

Solubilité

ethanol: 20 mg/mL, clear, colorless

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)

Clé InChI

ZFFFJLDTCLJDHL-UHFFFAOYSA-N

Description générale

5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.
Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.

Application

5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.
5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Consulter la Bibliothèque de documents

Robert W Shumaker et al.
Interdisciplinary topics in gerontology, 36, 147-161 (2008-06-05)
Data from wild populations demonstrate that orangutans have the slowest life history of all the great apes. In this chapter, we provide an overview of reproduction and life history traits of female orangutans in the wild and captivity. This comparison
Dana Rochester et al.
Fertility and sterility, 92(4), 1410-1415 (2008-10-03)
To determine whether obesity-related reproductive endocrine abnormalities in ovulatory women are reversible with weight loss. Observational cohort study. Healthy volunteers in an academic research environment. Women aged 18-48 years with regular menstrual cycles 21-40 days and a body mass index
Meena P Desai et al.
Journal of clinical laboratory analysis, 21(2), 55-60 (2007-03-28)
This study characterizes age-related changes in bone turnover markers in relation to ovarian hormones. The data (N = 236) were divided into 5-year age bands and three groups: premenopausal (Group I, N = 139), perimenopausal (Group II, N = 30)
N Santoro et al.
The Journal of clinical endocrinology and metabolism, 93(5), 1711-1721 (2008-02-21)
Reproductive hormones are incompletely characterized during the menopause transition (MT). Increased anovulation and decreased progesterone accompany progress through the MT. The Daily Hormone Study (DHS) of the Study of Women's Health Across the Nation (SWAN) included 848 women aged 43-53
Longitudinal fecal hormone analysis for monitoring reproductive activity in the female polar bear (Ursus maritimus)
Stoops MA, et al.
Theriogenology, 78(9), 1977-1986 (2012)
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