P3088

Anti-Parvalbumin Antibody

mouse monoclonal, PARV-19

• Synonyme(s) : Parvalbumin Antibody, Parvalbumin Antibody - Monoclonal Anti-Parvalbumin antibody produced in mouse
• Numéro MDL: MFCD00164711
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.44

Propriétés

• product name: Monoclonal Anti-Parvalbumin antibody produced in mouse, clone PARV-19, ascites fluid
• Source biologique: mouse
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: PARV-19, monoclonal
• Poids mol.: antigen 12 kDa
• Contient: 15 mM sodium azide
• Espèces réactives: fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat
• Technique(s): immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable (10-20K titer using Mouse skeletal muscle extract expressing Parvalbumin protein)
• Isotype: IgG1
• Numéro d'accès UniProt: P20472
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PVALB(5816) ; rat ... Pvalb(25269)

Description

Description générale

PVALB (parvalbumin) is a classical small member of the low molecular weight, acidic protein family known as calcium binding proteins (CaBPs) EF-hand superfamily. This protein shows a restricted pattern of expression in brain and muscle. It is a cytoplasmic high affinity CaBP.
Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the PARV-19 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Parvalbumin is a calcium-binding protein.

Spécificité

Recognizes parvalbumin in a Ca²⁺ ion-dependent manner. Does not react with other members of the EF-hand family such as calmodulin, intestinal calcium-binding protein, S100A2 (S100L), S100A6 (calcyclin), the α chain of S-100 (i.e. in S-100a and S-100ao), or the β chain (i.e. in S-100a and S-100b).

Immunogène

Frog muscle parvalbumin.

Application

Monoclonal Anti-Parvalbumin antibody produced in mouse has been used for immunohistochemistry, immunocytochemistry, and immunofluorescence.

Actions biochimiques/physiologiques

PVALB (parvalbumin) protein modulates relaxation in fast contracting muscles, where it localizes to type II (fast-twitch) mammalian skeletal muscle fibres in small mammals. This protein is a crucial regulator of neuronal intracellular calcium dynamics. PVALB protein maintains synaptic transmission during bursts, where it prevents presynaptic Ca²⁺ accumulation and hence the harmful effects of excess presynaptic Ca²⁺ levels. It also maintains synaptic transmission by allowing for linear information processing post-synaptically by preventing cumulative neuronal facilitation.

PVALB (parvalbumin) expression serves as marker for differentiating tumors as benign and malignant, in relation with thyroid lesions. Decreased expression of parvalbumin positive interneurons in rat model is associated with schizophrenia, and is known to disturb neuronal activity.

Forme physique

Liquid

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month.
For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable