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O8010

Sigma-Aldrich

Okadaic acid ammonium salt from Prorocentrum concavum

≥90% (HPLC), solid

Synonyme(s) :

OA

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About This Item

Formule empirique (notation de Hill):
C44H68O13 · NH3
Numéro CAS:
155716-06-6
Poids moléculaire :
822.03
Numéro MDL:
MFCD00153856
Code UNSPSC :
12352106
ID de substance PubChem :
24898053
Nomenclature NACRES :
NA.77

Source biologique

plant (Prorocentrum concavum)

Niveau de qualité

200

Pureté

≥90% (HPLC)

Forme

solid

Couleur

white

Solubilité

H2O: 0.1 mg/mL
DMSO: soluble
ethanol: soluble

Température de stockage

−20°C

Chaîne SMILES 

[H][N+]([H])([H])[H].[H][C@]1(CC[C@@H](O)[C@@]2(O[C@@H](CC(C)=C2)C(C)\C=C\[C@@]3([H])CC[C@@]4(CCC5O[C@H]([C@@H](O)C[C@H](C)C6O[C@@]7(CCCCO7)CC[C@H]6C)C(=C)[C@@H](O)[C@]5([H])O4)O3)O1)C[C@@](C)(O)C([O-])=O

InChI

1S/C44H68O13.H3N/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);1H3/b10-9+;/t26-,27-,28+,30+,31+,32+,33?,34+,35-,36-,37?,38+,39-,41-,42+,43-,44-;/m1./s1

Clé InChI

ZBOMSHVRJSJGNR-JBNKPAQWSA-N

Actions biochimiques/physiologiques

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301 + H311 + H331,H315

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

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Calyculin A, Discodermia calyx Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC₅₀ = 0.5-1 nM) and protein phosphatase 1 (PP1; IC₅₀ = 2 nM).

Sigma-Aldrich

208851

Calyculin A, Discodermia calyx

PTX-11 solution 20 μg/g in methanol (nominal concentration), certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

80099

PTX-11 solution

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