Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

MSST0045

Sigma-Aldrich

SILuProt TIMP2, Metalloproteinase inhibitor 2 human

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme


About This Item

Code UNSPSC :
23201100
Nomenclature NACRES :
NA.12

Le tarif et la disponibilité ne sont pas disponibles actuellement.

Produit recombinant

expressed in HEK 293 cells

Niveau de qualité

Essai

≥98% (SDS-PAGE)

Forme

lyophilized powder

Puissance

≥98% Heavy amino acids incorporation efficiency by MS

Adéquation

suitable for mass spectrometry (standard)

Numéro d'accès UniProt

Température de stockage

−20°C

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 4

Cet article
860061P860062C860063P
Brain SM Avanti Research™ - A Croda Brand

860062P

Brain SM

Egg SM Avanti Research™ - A Croda Brand

860061P

Egg SM

Brain SM Avanti Research™ - A Croda Brand

860062C

Brain SM

Milk SM Avanti Research™ - A Croda Brand

860063P

Milk SM

manufacturer/tradename

Avanti Research - A Croda Brand

manufacturer/tradename

Avanti Research - A Croda Brand

manufacturer/tradename

Avanti Research - A Croda Brand

manufacturer/tradename

Avanti Research - A Croda Brand

packaging

pkg of 1 × 1 g (860062P-1g), pkg of 1 × 25 mg (860062P-25mg), pkg of 1 × 200 mg (860062P-200mg), pkg of 1 × 500 mg (860062P-500mg)

packaging

pkg of 1 × 1 g (860061P-1g), pkg of 1 × 200 mg (860061P-200mg), pkg of 1 × 25 mg (860061P-25mg)

packaging

pkg of 1 × 2.5 mL (860062C-25mg), pkg of 2 × 4 mL (860062C-200mg)

packaging

pkg of 1 × 200 mg (860063P-200mg), pkg of 1 × 25 mg (860063P-25mg)

form

powder

form

powder

form

liquid

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Description générale

SILuProt TIMP2 is a recombinant, stable isotope-labeled human TIMP2 which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of TIMP2 in mass-spectrometry. SILuProt TIMP2 is a protein of 194 amino acids , with a calculated molecular mass of 21.7 kDa.

Actions biochimiques/physiologiques

While the mammalian TIMP family has four members, TIMP-2 is a unique family member in that in addition to inhibiting matrix metalloproteinases (MMPs), TIMP-2 selectively interacts with MT1-MMP to facilitate the cell-surface activation of pro-MMP-2.1 Thus, TIMP-2 functions both as an inhibitor of MMPs, and is required for the cellular mechanism of pro-MMP-2 activation. Recently, it was validated that combination of TIMP-2 with another urinary cell-cycle arrest biomarkers, i.e. the insulin-like growth factor-binding protein 7 (IGFBP7) may predict the risk of moderate and severe acute kidney injury (AKI) in critically ill patients. For postoperative surgical intensive care unit patients, a single urinary TIMP2•IGFBP7 test accurately identified patients at risk for developing AKI within the ensuing 12 hours and its inclusion in clinical risk prediction models significantly enhances their performance.

Séquence

CSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP

Forme physique

Supplied as a lyophilized powder containing phosphate buffered saline.

Informations légales

SILu is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique