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Principaux documents

M7504

Sigma-Aldrich

Mannan from Saccharomyces cerevisiae

Mannan from Saccharomyces cerevisiae

prepared by alkaline extraction

Synonyme(s) :

D-Mannan

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About This Item

Numéro CAS:
9036-88-8
Numéro MDL:
MFCD00131574
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Source biologique

bakers yeast (whole cell)

Niveau de qualité

300

Forme

powder

Activité optique

[α]/D 73 to 89 °, c = 1% (w/v) in water

Impuretés

<1.0% Low molecular weight saccharides (TLC)

Couleur

beige

Solubilité

water: ~50 g/L

Traces de cations

Na: <2%

Température de stockage

2-8°C

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Catégories apparentées

Description générale

Mannan is the main component of yeast cell wall polysaccharides broadly present in nature, such as in plants, bacteria, yeasts, and other organisms. It comprises a highly branched complex carbohydrate, an α-1,6 backbone with α-1,2- and α-1,3-attached mannose side chains.

Application

Mannan from Saccharomyces cerevisiae has been used to coat the microtiter wells to quantify the levels of mannose-binding lectin (MBL) using a mannan-binding enzyme-linked immunosorbent assay (ELISA).
Mannan from Saccharomyces cerevisiae has been used in a study to assess nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. [1] It has also been used in a study to investigate new lectins from bulbs of Croccus sativum. [2]

Actions biochimiques/physiologiques

Mannan exhibits several biological properties, including antiproliferative, antioxidant, and immunomodulatory. It is used as a hardener ingredient and as an emulsion stabilizer. Mannan is also involved in the inhibition of pathogen adherence, regulation of bacterial growth, and enhancement of the immune response.

Notes préparatoires

Prepared by method of Haworth.[3]

Autres remarques

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000429357
0000429357
0000425215
0000425215
0000393636

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Y Oda et al.
Biological & pharmaceutical bulletin, 16(10), 978-981 (1993-10-01)
Four isolectins were isolated from bulbs of Croccus sativum (saffron), using affinity chromatography on mannan-Sepharose 4B, gel filtration and ion-exchange column chromatography in the presence of 8 M urea. The relative molecular masses of these lectins were determined by gel
Michael L Patnode et al.
Cell, 179(1), 59-73 (2019-09-21)
Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with
Polysaccharides. Part XXIV. Yeast mannan.
Haworth, W.N., et al.
Journal of the Chemical Society, 784-791 (1937)
J A Roecklein et al.
The Journal of laboratory and clinical medicine, 119(6), 772-781 (1992-06-11)
The uptake of Mycobacterium avium complex (MAC) microorganisms by human peripheral blood monocytes (PBMs) and alveolar macrophages (AMs) is not well understood. We have previously shown, under opsonic conditions, that humoral factors are important in mediating the uptake of MAC
Tue Wenzel Kragstrup et al.
PloS one, 11(2), e0148486-e0148486 (2016-02-06)
In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission. However, the underlying temporal changes of such immune system abnormalities in the inflammatory response during treat-to-target strategies
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the molecular weight in Dalton

    1 answer

    1. The molecular weight is not analyzed on a lot to lot basis. It will be a mixture of polymers of variable molecular weights in the range of 34 - 62.5 kDa.

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Reviews

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  1. Merced, CA
    • Review 1
    • Vote 1
    5 out of 5 stars.

    Mannan

    Behaved as expected, appears to be as pure as advertised. Also was at a reasonable price.

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