M7316
Monoamine Oxidase A human
recombinant, expressed in baculovirus infected BTI insect cells
Synonyme(s) :
MAO-A, MAOA
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About This Item
Numéro MDL:
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54
Produits recommandés
Produit recombinant
expressed in baculovirus infected BTI insect cells
Niveau de qualité
Forme
liquid
Conditionnement
vial of ~2.5 mg
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... MAOA(4128)
Description générale
Monoamine Oxidase A contains binding sites for 8α-S-cysteinyl-FAD.
Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.
Application
Monoamine Oxidase A has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase A was found. It has also been used in a study to investigate an association between smoking and the inhibition of MAOA.
Actions biochimiques/physiologiques
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
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Les clients ont également consulté
Ryuichi Harada et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 62(2), 253-258 (2020-07-11)
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (S)-(2-methylpyrid-5-yl)-6-[(3-18F-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1)
J S Fowler et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14065-14069 (1996-11-26)
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis
Wenping Wang et al.
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain
Marcus A Maher et al.
Analytical and bioanalytical chemistry, 408(3), 695-703 (2015-11-18)
The need for rapid and cost-effective pre-screening protocols of the toxicological response of the vast array of emerging nanoparticle types is apparent and the emerging consensus on the paradigm of oxidative stress by generation of intracellular reactive oxygen species as
Vittorio Canale et al.
European journal of medicinal chemistry, 208, 112765-112765 (2020-09-20)
The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT6 receptor (5-HT6R) antagonists/MAO-B inhibitors using pharmacophore hybridization strategy. Our approach involved
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