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M4155

Sigma-Aldrich

Anti-Mouse IgG (Fab specific) antibody produced in goat

2.0 mg/mL, affinity isolated antibody

Synonyme(s) :

Anti-Mouse Fab Antibody, Anti-Mouse Fab Antibody - Anti-Mouse IgG (Fab specific) antibody produced in goat

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About This Item

Numéro MDL:
MFCD00162619
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

goat

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

secondary antibodies

Clone

polyclonal

Concentration

2.0 mg/mL

Technique(s)

Ouchterlony double diffusion: suitable
indirect ELISA: 1:15,000

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

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Description générale

IgG consists of four polypeptide chains, made of two identical 50 kDa γ heavy (H) chains and two identical 25 kDa κ or λ light (L) chains, which are connected by inter-chain disulfide bonds. IgG has four isotypes IgG1, IgG2, IgG3 and IgG4.

Application

Anti-Mouse IgG (Fab specific) antibody produced in goat has been used in the expression and purification of human platelet factor 4 (PF4) and anti-PF4 monoclonal antibodies.
Anti-Mouse IgG (Fab specific) antibody produced in goat was used as secondary antibody in immunocytochemical staining at a dilution of 1:10.

Actions biochimiques/physiologiques

IgG activates the classical pathway of the complement system. It neutralizes virus particles and toxins. IgG plays a critical role in antibody-dependent cell-mediated cytotoxicity (ADCC). It has the longest serum half life and might be associated with allergy.
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids. It provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.

Autres remarques

Antibody adsorbed with bovine, equine and human serum proteins.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jia Yuan et al.
Journal of integrative plant biology, 65(11), 2490-2504 (2023-08-07)
Soyasaponins are major small molecules that accumulate in soybean (Glycine max) seeds. Among them, type-A soyasaponins, fully acetylated at the terminal sugar of their C22 sugar chain, are responsible for the bitter taste of soybean-derived foods. However, the molecular basis
Distinct Specificity and Single-molecule Kinetics of the Interaction of Pathogenic and Non-Pathogenic anti-Platelet Factor 4/Heparin Antibodies with Platelet Factor 4
Litvinov RI, et al.
The Journal of Biological Chemistry, jbc-M113 (2013)
Shoshana Peller et al.
Oncogene, 22(30), 4648-4655 (2003-07-25)
The p53 tumor suppressor gene was found to play a role in the differentiation of several tissue types. We report here that p53-dependent apoptosis plays a role in the final stages of physiological differentiation of normoblasts, resulting in nuclear condensation
Qiang Sun et al.
Cell cycle (Georgetown, Tex.), 21(12), 1267-1279 (2022-03-12)
As a common cause of liver injury, hepatic ischemia/reperfusion injury (HIRI) happens in various clinical conditions including trauma, hepatectomy and liver transplantation. Since transcription factor Yin Yang 1 (YY1) was reported to be downregulated after ischemia/reperfusion (I/R) injury, we focused
S Peller et al.
Genes, chromosomes & cancer, 21(1), 2-7 (1998-01-27)
The TP53 gene has been extensively studied in patients with chronic myeloid leukemia (CML), both in chronic phase and in blast crisis. Mutations in the gene were found in up to 30% of the patients, especially among those in blast
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