M3047

Mizoribine

≥98% (TLC)

• Synonyme(s) : N′-(β-D-Ribofuranosyl)-5-hydroxy­imida­zole-4-carboxamide
• Formule empirique (notation de Hill) : C₉H₁₃N₃O₆
• Numéro CAS: 50924-49-7
• Poids moléculaire : 259.22
• NACRES: NA.77
• PubChem Substance ID: 24278546
• UNSPSC Code: 12352200
• MDL number: MFCD00057221
• Assay: ≥98% (TLC)

Propriétés

• Quality Segment: 200
• assay: ≥98% (TLC)
• storage temp.: 2-8°C
• SMILES string: NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O
• InChI: 1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
• InChI key: HZQDCMWJEBCWBR-UUOKFMHZSA-N

Description

Application

Mizoribine has been used in topical treatment to evaluate its effect on ocular surface damage of dry eye in B6 mice subjected to desiccating stress (DS). It has also been used as an inosine monophosphate dehydrogenase (IMPDH) inhibitor to test its in vivo efficacy.

Biochem/physiol Actions

Mizoribine is an imidazole nucleoside possessing strong immunosuppressive properties. It selectively blocks T-cell proliferation response to mitogenic and allo-antigenic stimulation. Mizoribine blocks the movement of T cells from G to S phase. In addition, it significantly decreases the number of B cells at the S, G, and M phases. Mizoribine inhibits de novo synthesis of nucleotides by inhibition of inosine monophosphate dehydrogenase. The resulting nucleotide depletion inhibits DNA synthesis.(3)

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H335,H360
• pcodes: P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges