I2273

3-Indoleacrylic acid

≥98% (HPLC), BioReagent

• Synonyme(s) : 3-(3-Indolyl)acrylic acid, IAA
• Formule empirique (notation de Hill): C₁₁H₉NO₂
• Numéro CAS: 1204-06-4
• Poids moléculaire : 187.19
• Beilstein: 6317
• Numéro CE : 214-872-7
• Numéro MDL: MFCD00005633
• Code UNSPSC : 12352106
• ID de substance PubChem : 24895972
• Nomenclature NACRES : NA.52

Propriétés

• Qualité: for molecular biology
• Niveau de qualité: 100
• Gamme de produits: BioReagent
• Essai: ≥98% (HPLC)
• Forme: powder
• Poids mol.: 187.19 g/mol
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)\C=C\c1c[nH]c2ccccc12
• InChI: 1S/C11H9NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-7,12H,(H,13,14)/b6-5+
• Clé InChI: PLVPPLCLBIEYEA-AATRIKPKSA-N

Description

Description générale

3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. This expression system requires that the gene of interest is cloned in plasmids containing the trpE promoter.

Application

3-Indoleacrylic acid has been used in the induction of ribokinase expression in E. coli.

Actions biochimiques/physiologiques

3-Indoleacrylic acid (IAA) is metabolized from tryptophan and this conversion is carried out by gut microflora. 3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. The IAA induced expression system requires the gene of interest cloned in plasmids containing the trp promoter. It promotes the barrier functionality of the intestinal epithelial cells. IAA also favors anti-inflammatory response and is regarded as a potential therapeutic to treat inflammatory bowel disease (IBD). It is also implicated in a variety of cellular processes including apoptosis, autophagy, cell proliferation and migration. In tumor cells, IAA is also reported to hinder tryptophan metabolism.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves