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H9538

Sigma-Aldrich

HNE-DMA

hexane solution, ≥85% (GC)

Synonyme(s) :

(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA

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About This Item

Formule empirique (notation de Hill):
C11H22O3
Poids moléculaire :
202.29
Numéro MDL:
MFCD07370138
Code UNSPSC :
12352200
ID de substance PubChem :
24724506
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

≥85% (GC)

Forme

hexane solution

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CCCCCC(O)\C=C\C(OC)OC

InChI

1S/C11H22O3/c1-4-5-6-7-10(12)8-9-11(13-2)14-3/h8-12H,4-7H2,1-3H3/b9-8+

Clé InChI

ATGIHMSJAARJTF-CMDGGOBGSA-N

Actions biochimiques/physiologiques

Stable form of HNE; toxic second messenger of free radicals.

Notes préparatoires

To prepare HNE from HNE-DMA: evaporate the hexane under a gentle stream of nitrogen at room temperature. Working at 4 °C, add 1 ml (5 mg size) or 0.4 ml (2 mg size) of 1 mM cold HCl and stir for 45 minutes, or alternatively, close the vial and shake for 30 minutes. Upon hydrolysis, the initially cloudy solution becomes almost clear. This solution now has a pH of ∼3, contains ∼5 mg (5 mg size) or ∼2 mg (2 mg size) of the aldehyde (HNE), and is stable for at least 24 hours if kept at 4 °C. 6.8 mg HNE-DMA in 1 mL of hexane solution, giving 5 mg of HNE after hydrolysis.It is recommended that the freshly prepared HNE solution be used immediately.

Mention d'avertissement

Danger

Classification des risques

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

Organes cibles

Central nervous system, Nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

-14.8 °F - closed cup

Point d'éclair (°C)

-26 °C - closed cup

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificats d'analyse (COA)

Lot/Batch Number
0000175421
0000175420
036M4615V
104M4623V
121M4614V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Héléna Alamil et al.
Toxicology letters, 331, 57-64 (2020-05-23)
Electrophilic compounds present in humans, originating from endogenous processes or pollutant exposures, pose a risk to health though their reaction with nucleophilic sites in protein and DNA. Among this chemical class, aldehydes are mainly present in indoor air and they
Femke van Diggelen et al.
PloS one, 14(3), e0213663-e0213663 (2019-03-23)
Parkinson's Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggregation of the pre-synaptic protein α-synuclein (aSN) into oligomers (αSOs) is believed to play a key role in PD pathology, but little is known about αSO
Thomas Van Hecke et al.
Foods (Basel, Switzerland), 10(11) (2021-11-28)
Oxidative reactions during cooking and gastrointestinal digestion of meat and fish lead to the formation of various lipid- and protein oxidation products, some of which are toxic. In the present study, it was investigated how the addition of 3% butter
Mutian Jia et al.
Nature immunology, 21(7), 727-735 (2020-06-17)
Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumors. Redox homeostasis is the balance of oxidative and reducing reactions present in all living systems. Yet, how the intracellular redox state
Wejdane El Manaa et al.
Autophagy, 17(12), 4363-4385 (2021-05-26)
Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventional

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