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H7791

Sigma-Aldrich

IL-17A human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

Synonyme(s) :

CTLA-8, IL-17

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About This Item

Numéro MDL:
MFCD01094096
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Interleukin-17A human, IL-17A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in HEK 293 cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

≤2 ng/mL EC50

Qualité

endotoxin tested

Poids mol.

dimer 30-35 kDa (glycosylated)

Conditionnement

pkg of 10 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

≤1 EU/μg

Numéro d'accès UniProt

Q16552

Température de stockage

−20°C

Informations sur le gène

human ... IL17A(3605)

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Actions biochimiques/physiologiques

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
IL-17A belongs to the IL-17 family and is produced by Th17 cells, a subset of T helper cells. Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. IL-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines, upregulates production of growth factors that promote angiogenesis, and enhances expression of adhesion molecules in fibroblasts.

Forme physique

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl pH 7.4+ 250 mM NaCl

Notes préparatoires

HumanKine Interleukin-17A (IL-17A), expressed in human HEK 293 cells, is a glycosylated homodimer with an apparent molecular mass of 30-35 kDa due to glycosylation. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Remarque sur l'analyse

The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF adult fibroblasts.

Informations légales

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Shu Zhu et al.
The Journal of experimental medicine, 207(12), 2647-2662 (2010-11-17)
Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this
Michael Notaras et al.
Molecular psychiatry (2021-06-24)
It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may increase risk of neuropsychiatric illness in offspring. However, little progress has been made in defining human-specific in utero neurodevelopmental
H Xiong et al.
International endodontic journal, 48(6), 505-511 (2014-07-22)
To investigate IL-17 expression in human pulpitis and to study the effects of IL-17 on the secretion of the chemokines IL-6 and IL-8 and the related signalling pathways. Samples of human dental pulp tissue were obtained from healthy controls and
Thomas Fabre et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3925-3933 (2014-09-12)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have
Kelly M Adams et al.
PloS one, 9(8), e103263-e103263 (2014-08-21)
The epithelium plays an active role in the response to inhaled pathogens in part by responding to signals from the immune system. Epithelial responses may include changes in chemokine expression, increased mucin production and antimicrobial peptide secretion, and changes in
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