H1007

L-Homoarginine hydrochloride

≥98% (TLC)

• Synonyme(s) : (S)-2-Amino-6-guanidinohexanoic acid hydrochloride
• Formule linéaire : H₂NC(=NH)NH(CH₂)₄CH(NH₂)CO₂H · HCl
• Numéro CAS: 1483-01-8
• Poids moléculaire : 224.69
• Numéro Beilstein : 4016621
• Numéro CE : 216-045-6
• Numéro MDL: MFCD00012622
• Code UNSPSC : 12352209
• ID de substance PubChem : 24895420
• Nomenclature NACRES : NA.26

Propriétés

• product name: L-Homoarginine hydrochloride, unnatural arginine analog
• Niveau de qualité: 200
• Pureté: ≥98% (TLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 213-215 °C (lit.)
• Solubilité: H₂O: soluble
• Application(s): peptide synthesis
• Chaîne SMILES: Cl[H].N[C@@H](CCCCNC(N)=N)C(O)=O
• InChI: 1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10;/h5H,1-4,8H2,(H,12,13)(H4,9,10,11);1H/t5-;/m0./s1
• Clé InChI: YMKBVNVCKUYUDM-JEDNCBNOSA-N

Description

Application

L-Homoarginine may be used to create non-natural proteins for studies of post-translational protein modifications. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements. L-Homoarginine is used to study the mechanisms of nitric oxide production by cells via nitric oxide synthase(s). L-Homoarginine is used as a selective mammalian alkaline phosphatase isoenzyme inhibitor. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin.

The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Actions biochimiques/physiologiques

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)