G6025

Geranylgeranyl pyrophosphate ammonium salt

solution, ≥95% (TLC), ~1 mg/mL in methanol: NH₄OH (7:3)

• Synonyme(s) : GGPP, all trans-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate ammonium salt
• Formule empirique (notation de Hill): C₂₀H₃₆O₇P₂ · xNH₃
• Numéro CAS: 6699-20-3
• Poids moléculaire : 450.44 (free acid basis)
• Numéro MDL: MFCD00156114
• Code UNSPSC : 12352211
• ID de substance PubChem : 24895243
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥95% (TLC)
• Forme: solution
• Conditionnement: vial of 200 μg
• Concentration: ~1 mg/mL in methanol: NH₄OH (7:3)
• Température de stockage: −20°C
• Chaîne SMILES: C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
• InChI: 1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
• Clé InChI: OINNEUNVOZHBOX-QIRCYJPOSA-N

Description

Application

Geranylgeranyl pyrophosphate ammonium salt has been used:

• in the preparation of 2.5X reaction buffer for Rab GGTase assay
• to add to the culture to further drive Hmg2 degradation
• as a substrate to carryout in vitro enzymatic assays for the characterization of the prenyltransferases
• to reverse the action of lovastatin and also used to examine the potential role of GGPP in the study to assess the effects of exposing the melanoma cell lines in the angiogenesis model as a co-culture to lovastatin in vitro

Actions biochimiques/physiologiques

Geranylgeranyl pyrophosphate (GGPP) is a major enzyme that participates in the secondary metabolism of chloroplast. GGPP synthase plays a key role in the biosynthesis of terpenoid. Protein geranylgeranylation, mediated by geranylgeranyl pyrophosphate participates in the development of the ventricular chamber. It also serves as a stage-specific signal to modulate the formation of cardiac cytoarchitecture the time of mid-gestation.

Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 51.8 °F - closed cup
• Point d'éclair (°C): 11 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter