F9765

Filipin complex

powder, ≥70% (UV)

• Synonyme(s) : Filimarisin
• Numéro CAS: 11078-21-0
• Numéro MDL: MFCD00131073
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• product name: Filipin complex from Streptomyces filipinensis, ≥70% (UV)
• Source biologique: Streptomyces sp. (Streptomyces filipinensis)
• Niveau de qualité: 200
• Pureté: ≥70% (UV)
• Forme: powder
• Solubilité: methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
• Spectre d'activité de l'antibiotique: fungi
• Mode d’action: cell membrane | interferes
• Température de stockage: −20°C
• InChI: 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
• Clé InChI: IMQSIXYSKPIGPD-YQRUMEKGSA-N

Description

Description générale

Chemical structure: macrolide

Application

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Actions biochimiques/physiologiques

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Autres remarques

Filipin contains 8 isomeric components, with filipin III as the major component.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable