E7881

Emodin

from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor

• Synonyme(s) : 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione, 1,3,8-Tri­hydroxy-6-methyl­anthra­quinone, 6-Methyl-1,3,8-tri­hydroxy­anthra­quinone, Archin, Emodol, Frangula-emodin, Frangulic acid, Rheum emodin
• Formule empirique (notation de Hill): C₁₅H₁₀O₅
• Numéro CAS: 518-82-1
• Poids moléculaire : 270.24
• Numéro Beilstein : 1888141
• Numéro CE : 208-258-8
• Numéro MDL: MFCD00001207
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278164
• Nomenclature NACRES : NA.77

Propriétés

• product name: Emodin, from Frangula bark, ≥90% (HPLC)
• Source biologique: Frangula bark
• Niveau de qualité: 200
• Pureté: ≥90% (HPLC)
• Solubilité: DMSO: soluble; aqueous base: soluble; ethanol: soluble
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
• InChI: 1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
• Clé InChI: RHMXXJGYXNZAPX-UHFFFAOYSA-N
• Informations sur le gène: human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)

Description

Description générale

Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum). It has antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase. It prevents the growth of prostate cancer cells. Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.

Application

Emodin has been used:

• to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
• as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
• to inhibit Tau aggregation
• for direct binding assay

Actions biochimiques/physiologiques

Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves