C7971

Cilostamide

≥97% (HPLC), PDE3 inhibitor, powder

• Synonyme(s) : 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Formule empirique (notation de Hill) : C₂₀H₂₆N₂O₃
• Numéro CAS: 68550-75-4
• Poids moléculaire : 342.43
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278337
• NACRES: NA.77
• MDL number: MFCD00673958

Propriétés

• Nom du produit: Cilostamide, phosphodiesterase inhibitor
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• solubility: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• SMILES string: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Gene Information: human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) ; rat ... Pde2a(81743), Pde4a(25638)

Description

Biochem/physiol Actions

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)