C4369

Calcipotriol hydrate

≥98% (HPLC), powder, Vitamin D3 analog

• Synonyme(s) : (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol, Calcipotriene
• Formule empirique (notation de Hill) : C₂₇H₄₀O₃ · xH₂O
• Numéro CAS: 112965-21-6
• Poids moléculaire : 412.60 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775060
• NACRES: NA.77
• MDL number: MFCD10567086
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Calcipotriol hydrate, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: room temp
• SMILES string: O.C[C@H](\C=C\[C@@H](O)C1CC1)C2CCC3\C(CCC[C@]23C)=C\C=C4\C[C@@H](O)C[C@H](O)C4=C
• InChI: 1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
• InChI key: XBKHACNRWFKJNC-MANNPBRJSA-N

Description

Biochem/physiol Actions

Calcipotriol is a synthetic derivative of calcitriol, or Vitamin D.

Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.

Informations sur la sécurité

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310,H317,H319,H361fd,H372
• pcodes: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1B - STOT RE 1
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves