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A6226

Sigma-Aldrich

AM251

>98% (HPLC), solid, cannabinoid receptor (CB1) antagonist

Synonyme(s) :

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

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About This Item

Formule empirique (notation de Hill):
C22H21N4OCl2I
Numéro CAS:
183232-66-8
Poids moléculaire :
555.24
Numéro MDL:
MFCD01861181
Code UNSPSC :
12352200
ID de substance PubChem :
24891069
Nomenclature NACRES :
NA.77

product name

AM251, >98% (HPLC), solid

Niveau de qualité

100

Pureté

>98% (HPLC)

Forme

solid

Couleur

white

Solubilité

DMSO: >10 mg/mL
H2O: insoluble

Auteur

Sanofi Aventis

Chaîne SMILES 

Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCCCC4

InChI

1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

Clé InChI

BUZAJRPLUGXRAB-UHFFFAOYSA-N

Informations sur le gène

mouse ... Cnr1(12801) , Cnr2(12802)
rat ... Cnr1(25248)

Application

AM251, a CB1 cannabinoid receptor antagonist, has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.

Actions biochimiques/physiologiques

AM251 is a CB1 cannabinoid receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

Salt content may vary.

Mentions de danger

H413

Conseils de prudence

P273 - P501

Classification des risques

Aquatic Chronic 4

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Direct-acting antivirals have significantly improved treatment outcomes in chronic hepatitis C (CHC), but side effects, drug resistance and cost mean that better treatments are still needed. Lipid metabolism is closely linked with hepatitis C virus (HCV) replication, and endocannabinoids are
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