A3650

Amikacin hydrate

aminoglycoside antibiotic

• Synonyme(s) : N¹-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A
• Formule empirique (notation de Hill) : C₂₂H₄₃N₅O₁₃ · xH₂O
• Numéro CAS: 1257517-67-1
• Poids moléculaire : 585.60 (anhydrous basis)
• UNSPSC Code: 51281632
• NACRES: NA.85
• PubChem Substance ID: 24890796
• EC Number: 253-538-5
• Beilstein/REAXYS Number: 1445422
• MDL number: MFCD11045969

Propriétés

• biological source: synthetic
• Quality Segment: 200
• form: powder
• color: white to almost white
• antibiotic activity spectrum: Gram-negative bacteria, mycobacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
• InChI: 1S/C22H43N5O13.H2O/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);1H2/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
• InChI key: DTSOZYYWEZJFSS-XTHCGPPUSA-N

Description

General description

Chemical structure: aminoglycoside

Application

Amikacin hydrate is used in antimicrobial susceptibility studies of organisms such as Mycobacterium tuberculosis and Ehrlichia phagocytophila.

Biochem/physiol Actions

Amikacin inhibits bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. It interferes with the translocation of tRNA from the A-site to the P-site.

Packaging

5G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)