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76200

Sigma-Aldrich

D-Panthenol

≥98.0% (NT)

Synonyme(s) :

(R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B

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About This Item

Formule empirique (notation de Hill):
C9H19NO4
Numéro CAS:
81-13-0
Poids moléculaire :
205.25
Numéro Beilstein :
1724947
Numéro CE :
201-327-3
Numéro MDL:
MFCD00065006
Code UNSPSC :
12352104
ID de substance PubChem :
57652627
Nomenclature NACRES :
NA.28

Source biologique

synthetic

Niveau de qualité

200

Pureté

≥98.0% (NT)

Forme

liquid

Activité optique

[α]20/D +30±1°, c = 5% in H2O

Impuretés

≤0.002% heavy metals
≤0.5% 3-aminopropanol

Résidus de calcination

≤0.1% (as SO4)

Couleur

colorless

Indice de réfraction

n20/D 1.496-1.500

Densité

1.20 g/mL at 20 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES 

CC(C)(CO)[C@@H](O)C(=O)NCCCO

InChI

1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1

Clé InChI

SNPLKNRPJHDVJA-ZETCQYMHSA-N

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Application


  • The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE(2) synthesis by keratinocytes.: This study investigates the protective effects of D-panthenol, combined with other compounds, against UVB-induced inflammation in keratinocytes. The results highlight D-panthenol′s role in skin care formulations aimed at reducing UV-induced damage and inflammation (Tan et al., 2024).

  • Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury.: This research explores the protective properties of D-panthenol in mitigating acute kidney injury caused by rhabdomyolysis. The findings suggest potential therapeutic applications for D-panthenol in renal protection and recovery (Semenovich et al., 2022).

  • Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery.: This clinical study examines the efficacy of eye drops containing D-panthenol in patients undergoing cataract surgery, demonstrating its potential to enhance postoperative recovery and eye health (Martone et al., 2022).

  • Common Cosmetic Compounds Can Reduce Air Pollution-Induced Oxidative Stress and Pro-Inflammatory Response in the Skin.: This study highlights the role of D-panthenol in protecting the skin against oxidative stress and inflammation caused by air pollution, emphasizing its importance in cosmetic formulations for urban environments (Hergesell et al., 2022).

Actions biochimiques/physiologiques

D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves

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X Hui et al.
International journal of cosmetic science, 29(4), 277-282 (2008-05-21)
The in vitro absorption of panthenol into and through the human nail was examined in this study. Panthenol, the alcohol form of pantothenic acid (vitamin B5), is believed to act as a humectant and improve the flexibility and strength of
Daisaku Kobayashi et al.
Journal of pharmacological sciences, 115(2), 230-234 (2011-01-25)
It has been reported that pantothenic acid (vitamin B5) and panthenol, an alcohol derivative of pantothenic acid, have beneficial moisturizing effects on the skin. However, few studies have investigated the mechanism of action of pantothenic acid on skin tissues. We
M Sachs et al.
Zeitschrift fur Ernahrungswissenschaft, 29(4), 270-283 (1990-12-01)
The aim of this study was the examination of the metabolism and mechanism of action of D-pantothenyl alcohol in patients with postoperative intestinal atony. Seven metabolically healthy patients were examined on the 4th day following colorectal surgery, before bowel activity
M Göbbels et al.
Klinische Monatsblatter fur Augenheilkunde, 209(2-3), 84-88 (1996-08-01)
In this controlled, randomized, double-masked study the effect of dexpanthenol-containing artificial tears (Siccaprotect) on patients with dry eyes was examined. 50 patients applied either dexpanthenol-containing artificial tears (Siccaprotect) or the identical, but free of dexpanthenol, eye drops five times daily
Fritz Ebner et al.
American journal of clinical dermatology, 3(6), 427-433 (2002-07-13)
Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid
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