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69453

Sigma-Aldrich

L-Homocysteine

≥98.0% (NT)

Synonyme(s) :

(S)-2-Amino-4-mercaptobutyric acid

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About This Item

Formule linéaire :
HSCH2CH2CH(NH2)COOH
Numéro CAS:
6027-13-0
Poids moléculaire :
135.18
Numéro CE :
227-891-0
Numéro MDL:
MFCD00151320
Code UNSPSC :
12352204
ID de substance PubChem :
329761669
Nomenclature NACRES :
NA.32

product name

L-Homocysteine, ≥98.0% (NT)

Niveau de qualité

100

Pureté

≥98.0% (NT)

Forme

powder

Activité optique

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

Couleur

white

Pf

263-265 °C

Application(s)

cell analysis

Maladie(s) pertinente(s)

Alzheimer′s disease

Température de stockage

−20°C

Chaîne SMILES 

N[C@@H](CCS)C(O)=O

InChI

1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1

Clé InChI

FFFHZYDWPBMWHY-VKHMYHEASA-N

Description générale

L-homocysteine is used to diagnose homocystinuria.

Application

L-homocysteine has been used as a supplement in cell culture media.

Actions biochimiques/physiologiques

Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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K Mehlig et al.
Heart (British Cardiac Society), 99(23), 1761-1765 (2013-09-10)
An elevated level of total plasma homocysteine (tHcy) has been associated with risk of coronary heart disease (CHD). The level of tHcy is affected by lifestyle, in addition to genetic predisposition. The methylene tetrahydrofolate reductase (MTHFR) 677C>T polymorphism (rs1801133) is
Sanne Visser et al.
American journal of obstetrics and gynecology, 211(4), 373-373 (2014-03-19)
The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. This was a systematic review
SAGE open medicine, 286054-286054 (2014)
Gwenaëlle Douaud et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9523-9528 (2013-05-22)
Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized
Babak Hooshmand et al.
Brain : a journal of neurology, 136(Pt 9), 2707-2716 (2013-08-29)
Elevated plasma total homocysteine is associated with increased risk of dementia/Alzheimer's disease, but underlying pathophysiological mechanisms are not fully understood. This study investigated possible links between baseline homocysteine, and post-mortem neuropathological and magnetic resonance imaging findings up to 10 years
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