14370

Bilirubine

purum, ≥95.0% (UV)

• Synonyme(s) : Bile pigment, Hemetoidin
• Formule empirique (notation de Hill) : C₃₃H₃₆N₄O₆
• Numéro CAS: 635-65-4
• Poids moléculaire : 584.66
• UNSPSC Code: 12352202
• NACRES: NA.25
• PubChem Substance ID: 57647150
• EC Number: 211-239-7
• Beilstein/REAXYS Number: 74376
• MDL number: MFCD00005499
• Assay: ≥95.0% (UV)
• Form: powder

Propriétés

• grade: purum
• Quality Segment: 100
• assay: ≥95.0% (UV)
• form: powder
• ign. residue: ≤0.5%
• SMILES string: CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C
• InChI: 1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
• InChI key: BPYKTIZUTYGOLE-IFADSCNNSA-N

Description

General description

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Application

Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.

Biochem/physiol Actions

Plus de 99 % de la bilirubine totale est transportée sous forme conjuguée à l′albumine. Des taux anormalement élevés de bilirubine peuvent provoquer des dommages neurologiques graves, mais des niveaux légèrement élevés sont associés à une protection contre le stress oxydant.

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Analysis Note

λ_max. ∼453 nm, mol. absorption >56100 (chloroform)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)