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Y0001151

Hydrastine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(1R,9S)-β-Hydrastine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C21H21NO6 · HCl
Numéro CAS:
5936-28-7
Poids moléculaire :
419.86
Numéro MDL:
MFCD00058100
Code UNSPSC :
41116107
ID de substance PubChem :
329831282
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

hydrastine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

−20°C

Chaîne SMILES 

Cl.COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34

InChI

1S/C21H21NO6.ClH/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19;/h4-5,8-9,18-19H,6-7,10H2,1-3H3;1H/t18-,19+;/m1./s1

Clé InChI

URBFHJWLYXILMP-VOMIJIAVSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrastine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Tyrosine hydroxylase inhibitor. Reduces dopamine content in PC12 cells.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

David J Edwards et al.
Journal of the American Pharmacists Association : JAPhA, 43(3), 419-423 (2003-07-03)
To determine the concentration of hydrastine and berberine, the primary alkaloids in herbal products containing goldenseal. Descriptive comparison of 20 products purchased at local pharmacies or health food stores; 17 products were labeled as containing goldenseal root and 3 products
Shou Yu Yin et al.
Neuropharmacology, 47(7), 1045-1052 (2004-11-24)
The inhibitory effects of (1R,9S)- and (1S,9R)-enantiomers of beta-hydrastine (BHS) on dopamine biosynthesis in PC12 cells were investigated. (1R,9S)-BHS decreased the intracellular dopamine content with the IC50 value of 14.3 microM at 24 h, but (1S,9R)-BHS did not. (1R,9S)-BHS was
Matthias Unger et al.
Electrophoresis, 26(12), 2430-2436 (2005-05-25)
The root extracts of goldenseal (Hydrastis canadensis L.) are popular phytomedicines for the treatment of gastrointestinal disorders and upper respiratory tract infections. Here we describe a simple and fast capillary zone electrophoresis (CZE) method with ultraviolet detection at 225 nm
James A Douglas et al.
Fitoterapia, 81(7), 925-928 (2010-06-17)
Seasonal variations in biomass and alkaloid contents of goldenseal (Hydrastis canadensis) were investigated. Five-year-old plants gave 5x the yield of roots and rhizomes of two-year-old plants, and summer growth gave significant increases in root biomass but not rhizomes. Berberine contents
E A Abourashed et al.
Journal of pharmaceutical sciences, 90(7), 817-822 (2001-07-18)
Goldenseal (Hydrastis canadensis L., Ranunculaceae) is an ingredient of various dietary supplements intended for enhancing general body immunity. Many goldenseal products are currently available in the United States, either alone or in combination with echinacea. In most products, the content
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